不用本金就能赚钱的方法

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现在位置不用本金就能赚钱的方法>技术资料不用本金就能赚钱的方法>行业动态>技术动态>Science:单细胞测序显示:同一个人的不同神经元DNA序列不一样

Science:单细胞测序显示:同一个人的不同神经元DNA序列不一样

互联网2013年11月5日 8:28 点击:3448



 

之前大家一直认为一个人体内的每个细胞都有相同的遗传信息,基因组的特殊表达模式使得不同细胞的功能各异。然而最近发表在2013年11月1日的Science杂志上的文章推翻了该观点。

不用本金就能赚钱的方法QUEDINGYIGERENDEBUTONGSHENJINGYUANDEJIYINZUZHINENGCAIYONGDANXIBAOJIYINZUCEXUDEFANGFA。SUOERKEYANJIUSUODEKEXUEJIACAIYONGDANXIBAOJIYINZUCEXUDEFANGFAFAXIANTONGYIGERENZHONGBUTONGDESHENJINGYUANJIYINZUCUNZAIDUOYANGXING。

不用本金就能赚钱的方法GAIWENZHANGDETONGXUNZUOZHEFred GageBOSHICHENG,YUWOMENZHIQIANDEXIANGFABUTONG,BUTONGSHENJINGYUANDEYICHUANBIAOJIBINGBUXIANGTONG,SHENJINGYUANJIYINZUSHIYOUBUTONGDEDNAPIANDUANPINJIEQILAIDE。

KEXUEJIACONGSANWEISIZHETINEIFENLILEYIBAIGESHENJINGYUAN,CAIYONGDANXIBAOCEXUJISHU,KEXUEJIASHITUXUNZHAODNAKAOBEISHUDEBIANYIXING(copy number variations,CNVs)。JIEGUOXIANSHI41%DESHENJINGYUANYONGYOUDUTEDECNV,ZHEIBIAOMINGZHEIXIESHENJINGYUANBINGBUSHILAIZIYUTONGYIGEQINBEN。

不用本金就能赚钱的方法GageBOSHICHENG,WOMENFAXIANYIGERENDEBUTONGSHENJINGYUANDNAXULIEBUYIYANG,GAIJIEGUORANGWOMENFEICHANGJINGYI,WOMENBIXUYAOSHEJIDUIZHAOSHIYANBIAOMINGGAIXIANXIANGBUSHISHIYANCAOZUOZAOCHENGDEJIAXIANG。

YUSHIKEXUEJIACAIYONGCEXUYOUDAODUONENGGANXIBAO(induced pluripotent stem cells ,iPSCs)FENHUADESHENJINGYUANDEFANGFAJINXINGYANJIU,LILUNSHANGLAIZIYUXIANGTONGBIAOPIXIBAODEiPSCsJIYINZUSHIXIANGTONGDE。

不用本金就能赚钱的方法GageBOSHICHENG,GAISHIYANZHENGMINGLEWOMENZHIQIANDEFAXIAN,CONGTONGYIiPSCPINXIZHONGFENHUAERLAIDESHENJINGYUANDEJIYINZUYEYOUGEYIDEQUESHI,KUOZENGDENGXIANXIANG。

YOUQUDESHIBIAOPIXIBAOBENSHENYESHIYOUYICHUANCHAYIDE,DANSHIMEIYOUSHENJINGYUANZHEIMEXIANZHU。McConnellBOSHICHENG,SHENJINGYUANBIBIAOPIXIBAOJIYINZUYOUGENGDADEDUOYANGXINGSHISHUODETONGDE。YINWEISHENJINGYUANYAOBICIGOUTONG,XINGCHENGPANGDAFUZADEWANGLUO。

XIBAODEJIYINZUBUTONGHENKENENGDAOZHICHANSHENGDERNAHEDANBAIZHIBUTONG,McConnellBOSHICHENG,RUGUOWOMENNENGDUIYIGEXIBAOJIJINXINGJIYINZUFENXIYEJINXINGZHUANLUZUFENXI,WOMENDUIXIBAOGONGNENGFENHUARENSHIHUIGENGSHENRU。

 

 


PMC:
PMID:

Mosaic Copy Number Variation in Human Neurons

McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH.

We used single-cell genomic approaches to map DNA copy number variation (CNV) in neurons obtained from human induced pluripotent stem cell (hiPSC) lines and postmortem human brains. We identified aneuploid neurons, as well as numerous subchromosomal CNVs in euploid neurons. Neurotypic hiPSC-derived neurons had larger CNVs than fibroblasts, and several large deletions were found in hiPSC-derived neurons but not in matched neural progenitor cells. Single-cell sequencing of endogenous human frontal cortex neurons revealed that 13 to 41% of neurons have at least one megabase-scale de novo CNV, that deletions are twice as common as duplications, and that a subset of neurons have highly aberrant genomes marked by multiple alterations. Our results show that mosaic CNV is abundant in human neurons.

(来源: 互联网 )


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