不用本金就能赚钱的方法

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现在位置不用本金就能赚钱的方法>技术资料不用本金就能赚钱的方法>行业动态>技术动态>刘如谦(David Liu):超越CRISPR,实现碱基任意转换与增删,可修正89%的人类遗传病

刘如谦(David Liu):超越CRISPR,实现碱基任意转换与增删,可修正89%的人类遗传病

BioWorld2019年10月23日 8:36 点击:603


不用本金就能赚钱的方法2019NIAN10YUE21RI,DANJIANJIBIANJIJISHUKAICHUANGZHE,BroadYANJIUSUOLIURUQIAN(David R. Liu)JIAOSHOUZAINatureZAZHIFABIAOTIWEI:Search-and-replace genome editing without double-strand breaks or donor DNA DEYANJIULUNWEN。GAIYANJIUKAIFALEYIZHONGQUANXINDEJINGZHUNJIYINBIANJIGONGJU——XIANDAOBIANJI(Prime Editor),WUXUYILAIDNAMOBANBIANKEYOUXIAOSHIXIANSUOYOU12ZHONGDANJIANJIDEZIYOUZHUANHUAN,ERQIEHAINENGYOUXIAOSHIXIANDUOJIANJIDEJINGZHUNCHARUYUSHANCHU(ZUIDUOCHARU44GEJIANJI,HUOSHANCHU80GEJIANJI)。

不用本金就能赚钱的方法Nature ZAZHIPINGLUNZHEIYIJISHUSHI“CHAOJINGQUEDEXINXINGJIYINBIANJIGONGJU”, Science ZAZHIPINGLUNTASHI“CHAOYUECRISPR”DEZHONGDATUPO,HAFODAXUEJIAOSHOU,CRISPRXIANQUQIAOZHI·QIUQI(George Church)SHENGZANZHEIYICHENGGUO:“CHAOZHEZHENGQUEFANGXIANGMAICHUDEYIDABU”。


不用本金就能赚钱的方法XIANDAOBIANJI(Prime Editor),JIANGCas9MEI(LANSE)HENIZHUANLUMEI(HONGSE)JIEHECHENGFUHEWU,ZAIgRNA(LVSE)DEYINDAOXIA,JIANGGAIFUHEWUDAIDAODNASHUANGLUOXUAN(HUANGSEHEZISE)DETEDINGWEIZHI,BINGBAOLIUZAIGAIWEIZHICHARUXINDNAXULIE。

CRISPRJIYINBIANJIJISHUSHIYIZHONGZAI2012NIANBEIFAMINGDEJIQIQIANGDADEJIYINZUBIANJIGONGJU,2013NIAN2YUE,ZHANGFENGDENGRENSHOUCIJIANGCRISPRJISHUYONGYURENLEIXIBAODEJIYINBIANJI,HENKUAIQUDELEYIXILIEHUIHUANGDECHENGGUO,MUQIANCRISPRJIYINBIANJIJISHUYIJINGKAISHIYONGYURENLEIYICHUANBINGZHILIAODELINCHUANGSHIYAN。DANSHI,MUQIANCRISPRJIYINBIANJIJISHURENGRANXIANDEYOUXIEBENZHUO。

不用本金就能赚钱的方法CRISPRJIYINBIANJIYOUSHIHUIGAIBIANTABUYINGGAIGAIBIANDEJIYIN,YEJIUSHISUOWEIDETUOBAXIAOYING,CIWAI,CRISPRJIYINBIANJIYILAIYUDNASHUANGLIANDUANLIE,CONGERKENENGDAOZHIJIYINBIANJIHOUDEXIBAOCHUXIANBUKEYUQIDEHUNLUAN,ZHEIXIEQUEXIANDECUNZAIXIANZHILEQIZAIJICHUYANJIUHENONGYEZHONGDESHIYONG,BINGZAIYIXUESHANGGOUCHENGANQUANYINHUAN。

2016NIAN4YUE20RI,LIURUQIANDENGRENZAI Nature FABIAOLUNWEN,SHOUCIKEYITONGGUOKEKAO、KEYUCEDEFANGFA,SHIXIANDUIGAIBIANHUOXIBAOJIYINZUZHONGDEDANGEJIANJIJINXINGXIUGAI。


2017NIAN10YUE25RI,LIURUQIANDENGRENJINYIBUSHENGJI,KAIFACHULEDANJIANJIBIANJIQI(Base Editor),JIANGCas9HEAPOBEC(BAOMIDINGTUOANMEI)ZHENGHE,NENGGOUZAIBUZAOCHENGDNASHUANGLIANDUANLIEDEQINGKUANGXIA,JIANGA-TJIANJIDUIZHUANHUANWEIG-CJIANJIDUI,SHIXIANDUIJIYINZUDIANTUBIANDEDINGDIANJIAOZHENGXIUFU。


XUDUOYICHUANXINGJIBINGSHIYOUDANGEJIANJITUBIANDAOZHIDE,YINCI,DANJIANJIBIANJIQIDECHUXIAN,WEIZHILIAOXUDUODANJIANJIYICHUANBINGTIGONGLEQIANGDADEFANGFA,LIURUQIANYEYINCIBEI Nature PINGWEI“2017NIANYINGXIANGSHIJIESHIDAKEXUERENWU”。

不用本金就能赚钱的方法DANSHI,DANJIANJIBIANJIQIYOUJUXIANXING,BINGBUNENGRENYIBIANJISUOYOUJIANJI,ERQIE,2019NIAN3YUE1RI,ZHONGGUOKEXUEJIAYANGHUI、GAOCAIXIAGEZIZAI Science FABIAOYANJIULUNWEN,ZHENGSHIDANJIANJIBIANJIQICUNZAIYANZHONGDEYILIAOZHIWAIDETUOBAXIAOYING,ZHEIYEWEIYUANBENQIANJINGLEGUANDEDANJIANJIBIANJIJISHUMENGSHANGLEYICENGYINYING。

不用本金就能赚钱的方法BUNENGRENYIBIANJISUOYOUJIANJI,CUNZAITUOBAXIAOYING,ZHEISHIDANJIANJIBIANJIJISHUMIANLINDELIANGDAWENTI,WEILEJIEJUEZHEILIANGGEWENTI,XUDUOZHUOYUEDEKEXUEJIAZAIBUXIENULI,YIQIKAIFACHUXIAOGUOGENGHAO、TUOBAXINGGENGDIDEDANJIANJIBIANJIXITONG。

WEILEJIEJUEZHEILIANGGEWENTI,LIURUQIANTUANDUIZAICas9MEIHEgRNALIANGFANGMIANJINXINGLEZHONGDAGAIZAO:

YISHIGAIZAOgRNA,ZAIQI3’MODUANZENGJIALEYIDUANRNAXULIE,XINGCHENGSUOWEIDEpegRNA;

ERSHIGAIZAOCas9MEI,JIANGCas9MEIDEBIANTI(H840ATUBIANXING,ZHIQIEDUANHANPAMDEBADIANDNALIAN)YUNIZHUANLUMEIRONGHE,XINGCHENGRONGHEDANBAIFUHETI。

pegRNADE3’DUANXULIEYOUSHUANGZHONGJIAOSE,YIDUANXULIEZUOWEIYINWUJIEHEWEIDIAN(PBS),YUDUANLIEDEBADNALIAN3’MODUANHUBUYIQISHINIZHUANLUGUOCHENG,LINGYIDUANXULIEZESHINIZHUANLUDEMOBAN(RTMOBAN),QISHANGXIEDAIYOUMUBIAODIANTUBIANHUOCHARUQUESHITUBIANYISHIXIANJINGZHUNDEJIYINBIANJI。

 

LIURUQIANTUANDUIDUI Prime Editor ZAIRENLEIHEXIAOSHUXIBAOZHONGJINXINGLE175ZHONGYISHANGDEJIYINBIANJISHIYAN,CHENGGONGXIUFULEDAOZHILIANZHUANGXIBAOXINGPINXUEZHENGHETay-SachsBINGDEJIYINTUBIAN。

LIANZHUANGXIBAOXINGPINXUEZHENG,SHIYIZHONGCHANGRANSETIXIANXINGYICHUANBING,YINBIANMAXUEHONGDANBAIDEJIYINZHONGFASHENGLEADAOTDEDANJIANJITUBIAN,DAOZHIXUEHONGDANBAIβ-TAILIANDI6WEIANJISUANGUANSUANBIANCHENGXIEANSUAN,GOUCHENGLIANZHUANGXUEHONGDANBAI,QUDAILEZHENGCHANGXUEHONGDANBAI。GAIJIBINGDECHUNHEZIHENNANCUNHUODAOCHENGNIAN。

不用本金就能赚钱的方法Tay-SachsBING,SHIYIZHONGCHANGRANSETIYINXINGYICHUANBING,YINHEXAJIYINFASHENGTUBIAN,DUOCHU4GEJIANJI,DAOZHIHEXAJIYINBIANMADEZHIZHIFENJIEMEISHIHUO,CONGERDAOZHISHENJINGJIEGANZHIZAIDANAOZHONGJUJIZHIZHONGDUSHUIPING,TONGCHANGHUANZHEZHINENGCUNHUOZHILIANGSANSUI,GAIJIBINGZAIYOUTAIRENZHONGFABINGLVXIANGDUIJIAOGAO。

ZHEILIANGZHONGYICHUANBING,SHIYONGCHUANTONGDEJIYINZUBIANJIXITONGYAOMEWUFAXIUFU,YAOMEXIAOLVDIXIA。

不用本金就能赚钱的方法ERLIURUQIANTUANDUISHIYONG Prime Editor CHENGGONGXIUFULEZHEILIANGZHONGJIYINTUBIAN,BUJINXIAOLVDADATIGAO,ERQIETUOBAXIAOYINGGENGDI,LIURUQIANTUANDUIZAILUNWENZHONGBIAOSHI,GAIJISHU“YUANZESHANGKEYIXIUFU75000ZHONGYIZHIZHIBINGXINGRENLEIYICHUANBIANYIDE89%”。

WEILECUJINXIANDAOBIANJI(Prime Editor)FAZHAN,JINYIBUJIANYANHEGAIJINZHEIZHONGXINXINGJIYINBIANJIFANGSHI,LIURUQIANTUANDUIYIXIANGXUESHUJIEHEFEIYINGLIZUZHIMIANFEIGONGKAIZHEIYIXITONG。

不用本金就能赚钱的方法JULEJIE,LIURUQIANYIWEIRAOZHEIXIANGXINJIANJIBIANJIGONGJUPrime EditorCHUANGJIANLEXINGONGSI Prime Medicine 。ZHEIYESHILIURUQIANZUOWEICHUANGSHIRENHUOLIANHECHUANGSHIRENDEDIQIJIAKEJIGONGSI。

ZHIQIANLIURUQIANYUZHANGFENGDENGRENYILIANHECHUANGJIANLESANJIAJIYINBIANJILINGYUGONGSI:JIYINBIANJIYILIAOGONGSIEditas Medicine、DANJIANJIBIANJIGONGSIBeam Therapeutis、JIYINBIANJINONGYEGONGSIPairwise Plants。

 

张锋教授(左)、David Liu教授(中)、J. Keith Joung教授(右)

QIZHONG,Editas MedicineYIJINGCHENGGONGSHANGSHI,Beam TherapeutisYEYIJINGTIJIAOSHANGSHISHENQING,Pairwise PlantsYIHUODESHUQIANWANMEIYUANRONGZI。


(来源: BioWorld )


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