不用本金就能赚钱的方法

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现在位置不用本金就能赚钱的方法>技术资料不用本金就能赚钱的方法>行业动态>技术动态>Cell Research:一个新的Wnt信号通路小分子抑制剂15-oxospiramilactone

Cell Research:一个新的Wnt信号通路小分子抑制剂15-oxospiramilactone

互联网2011年2月24日 13:45 点击:1422

WntXINHAOTONGLUSHISHENGWUZAOQIFAYUGUOCHENGZHONGYIGEFEICHANGBAOSHOUDEXINHAOTONGLU。ZHENGCHANGDEWntXINHAOTONGLUZHONGWntPEITIYUSHOUTIFrizzledHELRP5/6JIEHEHOU,KEYIYIZHIAPCDENGZUCHENGDEJIANGJIEFUHEWU,SHIXIBAOZHINEIDEβ-cateninDEYIWENDINGHEJILEIBINGJINYIBURUHE,TONGGUOYUZHUANLUYINZITCF/LEFJIEHE,KAIQIXIAYOUJIYINDEZHUANLU。YICHANGJIHUODEWntXINHAOBUZAISHOUDAOJIANGJIEFUHEWUDEDIAOJIEBINGQIEYUDUOZHONGZHONGLIUFASHENG、FAZHANGUANXIMIQIE,YOUQISHIWntXINHAOZHONGDEGUANJIANFENZIAPCTUBIANKEYIZHIJIEDAOZHIJIECHANGAI。WntXINHAOTONGLUYOUQISHIXIAYOUDEβ-catenin/TCF4ZHUANLUFUHEWUSHIJINNIANLAIXINGQIDEYIGEZHILIAOJIECHANGAIDENGAIZHENGDEYAOBA。

2月15日,国际学术期刊Cell Research不用本金就能赚钱的方法 在线发表了中科院上海生科院生化与细胞所李林研究组的最新研究成果。在这项工作中,王伟等人发现了一个新的Wnt信号通路的小分子抑制剂15-oxospiramilactone,并初步揭示了其作用机制和治疗结肠癌的潜力。

不用本金就能赚钱的方法NC043 (15-oxospiramilactone) SHIYIGEBANHECHENGDETIELEIHUAHEWU,QIMUTILAIYUANYUYIZHONGYONGLAIXIAOYANZHITENGDECHUANTONGZHONGCAOYAOSpiraea japonica。SHIYANZHENGMINGNC043TONGGUODIAOJIENEIYUANβ-catenin/TCF4ZHUANLUFUHEWUDEXINGCHENGYOUXIAODIYIZHIWntXIAYOUBAJIYINDEBIAODA。NC043KEYISHIJIECHANGAIXIBAOZUZHIZAIG2/MQI,BINGQIEDUIYUJIECHANGAIXIBAODESHENGZHANGDEYIZHIMINGXIANDAYUZHENGCHANGJIECHANGSHANGPIXIBAO。YIZHILIUSHIYANZHENGMINGNC043KEYIZAIHENDIJILIANGJIUDUIJIECHANGAIXIBAOXINGCHENGDEYIZHIZHONGLIUQIDAOHENHAODEYIZHIXIAOGUOTONGSHIDUILAOSHUTIZHONGMEIYOUYINGXIANG。ZHEIXIESHIYANJIEGUOBIAOMINGNC043YOUKENENGCHENGWEIYIGEZHILIAOJIECHANGAIDEYAOWUXIANDAOHUAHEWU。GUANYUQIZHIJIEZUOYONGDEBADIANHECHENGYAOXINGDEYANJIUZHENGZAIJINXINGDANGZHONG。

该研究课题与中科院昆明植物所郝小江研究组合作完成,获得国家科技部、国家自然科学基金委和上海市科委的经费资助。该成果已申请了相关专利。
原文出处:

Cell Research不用本金就能赚钱的方法 advance online publication 15 February 2011; doi: 10.1038/cr.2011.30

A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis

Wei Wang1, Haiyang Liu2, Sheng Wang1, Xiaojiang Hao2 and Lin Li1

Abstract

The Wnt/β-catenin signaling pathway is a highly conserved pathway in organism evolution and regulates many biological processes. Aberrant activation of the Wnt/β-catenin signaling pathway is closely related to tumorigenesis. In order to identify potent small molecules to treat the over-activated Wnt signaling-mediated cancer, such as colon cancer, we established a mammalian cell line-based reporter gene screening system. The screen revealed a diterpenoid derivative, 15-oxospiramilactone (NC043) that inhibits Wnt3a or LiCl-stimulated Top-flash reporter activity in HEK293T cells and growth of colon cancer cells, SW480 and Caco-2. Treatment of SW480 cells with NC043 led to decreases in the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin , as well as decreases in the protein levels of Cdc25c and Cdc2. NC043 did not affect the cytosol-nuclear distribution and protein level of soluble β-catenin, but decreased β-catenin/TCF4 association in SW480 cells. Moreover, NC043 inhibited anchorage-independent growth and xenograft tumorigenesis of SW480 cells. Collectively these results demonstrate that NC043 is a novel small molecule that inhibits canonical Wnt signaling downstream of β-catenin stability and may be a potential compound for treating colorectal cancer.

Keywords: Wnt; small molecule; inhibitor; tumorigenesis

(来源: 互联网 )


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