不用本金就能赚钱的方法

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现在位置不用本金就能赚钱的方法>技术资料不用本金就能赚钱的方法>行业动态>新品动态>噻托溴铵能倍乐可有效改善哮喘症状及预防急性加重

噻托溴铵能倍乐可有效改善哮喘症状及预防急性加重

美通社2013年5月25日 9:51 点击:1009

III期临床试验结果:噻托溴铵*能倍乐(Respimat)® 可有效治疗接受至少包括ICS/LABA治疗方案后仍然伴有症状的哮喘患者,而且不依赖于患者年龄、过敏状态、吸烟状况和支气管扩张剂反应性

  • 经由能倍乐(Respimat)® 软雾吸入器给药的噻托溴铵应用于接受至少包括ICS [a]/LABA [b]治疗方案后仍然伴有症状的广泛的患者人群,可延长距首次重度急性加重的时间和距首次哮喘恶化事件的时间
  • 噻托溴铵可针对性地改善哮喘患者的肺功能,这种改善并非源于患者合并慢性阻塞性肺疾病(COPD)

BINXIFANIYAZHOUFEICHENG2013NIAN5YUE23RIDIAN /MEITONGSHE/ -- ZAIJIESHOULEZHISHAOBAOKUOICS/LABADEZHILIAOFANGANHOURENGRANBANYOUZHENGZHUANGDEXIAOCHUANHUANZHEZHONG,JINGYOUNENGBEILE(Respimat)® RUANWUXIRUQIJIYAODESAITUOXIUANKEYANZHANGJUSHOUCIZHONGDUJIXINGJIAZHONGDESHIJIANHEJUSHOUCIXIAOCHUANEHUASHIJIANDESHIJIAN。ZHEIYIGAISHANZUOYONGBUYILAIYUHUANZHEDENIANLING、GUOMINZHUANGKUANG、XIYANZHUANGKUANGHEZHIQIGUANKUOZHANGJIFANYINGXING。[1]

ZAIJIESHOULEZHISHAOBAOKUOICS/LABADEZHILIAOFANGANHOURENGRANBANYOUZHENGZHUANGDEXIAOCHUANHUANZHEZHONG,JINGYOUNENGBEILE(Respimat)(R) RUANWUXIRUQIJIYAODESAITUOXIUANKEYANZHANGJUSHOUCIZHONGDUJIXINGJIAZHONGDESHIJIANHEJUSHOUCIXIAOCHUANEHUASHIJIANDESHIJIAN。ZHEIYIGAISHANZUOYONGBUYILAIYUHUANZHEDENIANLING、GUOMINZHUANGKUANG、XIYANZHUANGKUANGHEZHIQIGUANKUOZHANGJIFANYINGXING。

 

这也是来自预先设定的、基于 PrimoTinA- asthmaTM不用本金就能赚钱的方法  III期临床试验数据的亚组分析的主要结果 ,这些数据已在宾夕法尼亚州费城举办的美国胸科学会(ATS)2013年会上首次公布。[1]

此外,有关PrimoTinA-asthmaTM 研究的患者人群的基线期特征的详细分析结果也已在此次会议上公布[2]。上述分析结果显示,根据PrimoTinA asthmaTM 研究所纳入的患者人群的发病年龄、症状持续时间、吸烟史缺失、过敏状态和支气管扩张剂反应性,可以合理地确认,入组此项III期临床试验的患者患有哮喘,而不是COPD。[2]

在介绍PrimoTinA-asthmaTM 不用本金就能赚钱的方法研究亚组分析结果的时,来自荷兰Groningen大学医学中心的Huib A M Kerstjens教授评价道:“这些结果显示,噻托溴铵可有效应用于在接受了中等剂量至大剂量吸入型糖皮质激素(ICS)加长效B受体激动剂(LABA)的标准联合治疗方案后仍然伴有症状、并发生哮喘急性加重的广泛的患者人群。此外,在加用噻托溴铵之后所出现的首次重度急性加重的时间的延后和首次哮喘恶化事件的时间的延后并不局限在特定的患者亚组人群中。

“JULIERYAN,ZHEIXIEGAISHANXIAOGUOZAILAONIANHUANZHEHENIANQINGHUANZHEZHIJIAN、ZAIBANYOUGUOMINZHUANGTAIHEBUBANYOUGUOMINZHUANGTAIDEHUANZHEZHIJIAN、ZAIKENIXINGJIAOHAOHEKENIXINGJIAOCHADEHUANZHEZHIJIAN、ZAIJIWANGXIYANZHEHECONGWEIXIYANDEHUANZHEZHIJIANDOUSHIXIANGSIDE。”KerstjensJIAOSHOURUCIJIESHIDAO。

考虑到噻托溴铵应用于COPD治疗的有效性以及噻托溴铵在合并哮喘特征的COPD患者中所观察到的疗效,非常重要的一点就是需要评估被纳入PrimoTinA-asthmaTM不用本金就能赚钱的方法  III期临床试验的患者是否真正仅仅患有哮喘。

在介绍PrimoTinA-asthmaTM 研究的患者人群的基线期特征的详细分析结果的时,来自英国Royal Devon and Exeter医院的呼吸科顾问医师David Halpin教授如此说道:“这些结果为我们提供了证据,即这些显示了噻托溴铵疗效的研究所入组的患者具有哮喘的临床特点,而不是COPD。所有与COPD的相似之处均源自患者的哮喘病程较长。因此,在PrimoTinA-asthmaTM 研究中所显示的疗效反映出对患者哮喘的改善作用。”Halpin教授如此总结道。

在已经使用所有现有药物治疗的哮喘患者中,至少有40%的患者仍然伴有临床症状,并可能发生令人生畏的、甚至是危及生命的哮喘急性加重(哮喘发作)。[3]被纳入PrimoTinA-asthmaTM 不用本金就能赚钱的方法研究的所有患者是在接受了至少包括ICS/LABA的治疗方案之后仍然伴有症状的患者。

PrimoTinA-asthmaTM 不用本金就能赚钱的方法研究(1和2)包括两项双盲、平行分组的临床试验,所纳入的哮喘患者年龄为18至75岁、哮喘病程大于等于5年、均在40岁之前明确诊断。患者可以是终身未曾吸烟者,也可以是既往吸烟者(至少达到10包-年[c])并且在入组之前戒烟至少一年。[1]

共有912名患者随机接受额外的噻托溴铵能倍乐(Respimat)(Respimat)® 5 ug治疗(n=456)或额外的安慰剂治疗(n=456),疗程为48周。除了ICS/LABA之外,入组PrimoTinA-asthmaTM 研究的患者也被允许接受其他的合并治疗药物,包括抗组胺药物、抗过敏药物、鼻用糖皮质激素和奥马珠单抗。[1,2]

PrimoTinA-asthmaTM 研究所纳入患者的哮喘诊断参照目前的全球哮喘倡议(GINA)指南所制定的标准。[2]研究排除了COPD患者或其他肺部疾病的患者。[2]

ZAIZONGTIYANJIURENQUNZHONG,JIAYONGSAITUOXIUANNENGBEILE(Respimat)® DEHUANZHEDESHOUCIZHONGDUJIXINGJIAZHONGDESHIJIANCHUXIANYANHOU(FENGXIANXIAJIANGWEI21%;FENGXIANBIWEI0.79;p=0.03)。YUANWEIJIZUHUANZHEXIANGBI,SAITUOXIUANZUHUANZHEDESHOUCIXIAOCHUANEHUASHIJIANDESHIJIANYECHUXIANLEYANHOU(FENGXIANXIAJIANGWEI31%;FENGXIANBIWEI0.69;pXIAOYU0.001)。[1]ZHONGDUJIXINGJIAZHONGDEDINGYIWEIXUYAOKAISHISHIYONGQUANSHENXINGTANGPIZHIJISUZHILIAOHUOXUYAOJIANGQUANSHENXINGTANGPIZHIJISUJIYAOJILIANGFANBEIDEXIAOCHUANBINGQINGDEEHUA。[1]

不用本金就能赚钱的方法YAZUFENXIJIEGUOXIANSHI,ZAIJIAYONGSAITUOXIUANNENGBEILE(Respimat)®HOU,WULUNSHIJUSHOUCIZHONGDUJIXINGJIAZHONGSHIJIANDEGAISHAN,HAISHIJUSHOUCIXIAOCHUANEHUASHIJIANDESHIJIANDEGAISHAN,JUNBUYILAIYUHUANZHEDEJIXIANQITEZHENG,YEBUJUXIANYUTEDINGDEYAZUHUANZHERENQUN。

PrimoTinA-asthmaTM 研究是纳入患者人数超过4000人的名为“UniTinA-asthma®研究”的大规模全球型III期临床试验项目的一部分。

“XIANGDANGYIBUFENXIAOCHUANHUANZHEZAIJIESHOULEXIANYOUZHILIAOXUANZEHOURENGRANBANYOULINCHUANGZHENGZHUANG,ERUniTinA-asthma® SHIYANXIANGMUZHIZAITANSUOSAITUOXIUANNENGFOUMANZUSHANGSHUMINGQUEERWEIBEIMANZUDEZHILIAOXUQIU。ZHEIYISHIYANXIANGMUYEZHANSHILEWOMENZHILIYUKAIFASAITUOXIUANNENGBEILE(Respimat)®YIYONGYUKENENGCONGXINXINGZHILIAOFANGFAZHONGHUOYIDEGUANGFANDEXIAOCHUANHUANZHERENQUNDENULI。”BOLINGEYINGEHANGONGSIQUANQIUGAOJIYIXUEFUZONGCAIKlaus DugiBOSHIRUCISHUODAO。

供编辑参考信息

关于UniTinA-asthma™  

PrimoTinA-asthma™ YANJIUSHIBOLINGEYINGEHANGONGSIDEDAGUIMOQUANQIUXINGIIIQILINCHUANGSHIYANJIHUAUniTinA-asthma™ZHONGDEYIBUFEN,CIXIANGSHIYANZHIZAIMINGQUEJINGYOU NENGBEILE(Respimat)® SoftMist™XIRUQI(SMI)JIYAODESAITUOXIUANYINGYONGYUXIAOCHUANHUANZHEDELIAOXIAOHEANQUANXING。

不用本金就能赚钱的方法UniTinA-asthma™BAOKUOSHUXIANGZHENDUISAITUOXIUANNENGBEILE(Respimat)®YINGYONGYUYIJINGJIESHOUCHANGGUIZHILIAODEBANYOUBUTONGYANZHONGCHENGDUDECHIXUXINGXIAOCHUANDECHENGNIANREN、QINGSHAONIANHEERTONG(1SUIYISHANG)RENQUNDELINCHUANGSHIYAN。

MUQIANDEIIIQILINCHUANGSHIYANJIHUAYOU11XIANGSHIYANZUCHENG,JIHUAZAIQUANQIU150DUOGEYANJIUZHONGXINNARUCHAOGUO4000MINGHUANZHE。LAIZIQIZHONGLIANGXIANGIIIQILINCHUANGSHIYANDESHUJUYIZAI2012NIANERSDAHUISHANGSHOUCIYUYIGONGBU。[4,5]

UniTinA-asthma™ IIIQILINCHUANGSHIYANJIHUAZHENGZAIZHILIYUJIEJUEJIESHOUXIANYOUZHILIAOHOURENGRANBANYOUZHENGZHUANGDEHUANZHESUOCUNZAIDEWEIBEIMANZUDEZHILIAOXUQIU。 

GUANYUXIAOCHUAN

不用本金就能赚钱的方法XIAOCHUANSHIYIZHONGYIQIDAOYANZHENGHEZHIQIGUANSHOUSUOWEITEZHENGDEMANXINGJIBING,KEDAOZHIJINCHUFEIBUDEQILIUFASHENGSHOUXIANHEQIDAOZHANYESHENGCHENGZENGDUO[6]。

不用本金就能赚钱的方法DANGXIAOCHUANHUANZHEJIECHUDAOMOUZHONGXIAOCHUANYOUFAYINSU(LIRU,GANRAN、HUAFEN、YANWU),QIQIDAOJIUHUICHUXIANYANZHENG、ZHONGZHANGHESHOUSUO,BINGCHANSHENGGUODUODEZHANYE。ZHEIXIEFANYINGDAOZHIQIDAOBIANDEXIAZHAIHEYIJIRE,CONGERDAOZHIHUXIKUNNAN[6]。

不用本金就能赚钱的方法XIAOCHUANHUANZHEHUIFANFUFASHENGCHUANXI、QICU、XIONGMENHEKESOUZHENGZHUANG[6]。

QUANQIUFANWEINEIDEXIAOCHUANHUANZHERENSHUJIEYUYIYIZHISANYI,ZHEIYISHUZIDAO2025NIANYOUWANGZENGZHISIYIZHISIYIWUQIANWAN[7,8]。XIAOCHUANHUANBINGLVZAIGONGYEHUAGUOJIAZHONGSHIZUIGAODE。ZAIQUANQIUFANWEINEI,MEINIANYOUXIAOCHUANSUODAOZHIDESIWANGBINGLISHUYUEWEISHIBAWANLI[8],JINGUANXIAOCHUANSIWANGLVCUNZAIJIAODADEQUYUCHAYI[9]。

XIAOCHUANSHIBANYOUZUIGAODEJINGJIZHICHUDEMANXINGJIBINGZHONGDEYIZHONG。ZAIQUANQIUFANWEINEI,YUXIAOCHUANXIANGGUANDEJINGJIZHICHUCHAOGUOLEJIEHEBINGHEHIV/AIDSJINGJIZHICHUDEZONGHE。

不用本金就能赚钱的方法TONGGUOGUIBIJIECHUXIAOCHUANYOUFAYINSU,XIAOCHUANYANZHONGCHENGDUKEDEYIJIANGDI。JINGUANXIAOCHUANSHANGBUNENGBEIZHIYU,TONGGUOHELIDEJIBINGGUANLIJIUKEKONGZHIBINGQING,BINGSHIHUANZHEXIANGYOUJIAOGAODESHENGHUOZHILIANG。DANSHI,LIUXINGBINGXUESHUJUXIANSHI,JINGUANYIJINGJIESHOUZHILIAO,ZHISHAOYOU40%DECHENGNIANXIAOCHUANHUANZHERENGRANBANYOULINCHUANGZHENGZHUANG,QIRICHANGSHENGHUOYEHUISHOUDAOYINGXIANG,SHENZHIYOUKENENGXUYAOJIZHENZHILIAO。[3]ZHEIXIEHUANZHEKECONGXINXINGZHILIAOXUANZEZHONGHUOYI。

不用本金就能赚钱的方法[*] QINGZHUYI:SAITUOXIUANJINGYOU Respimat®JIYAOSHANGWEIZHUCEYONGYUXIAOCHUANZHILIAO,YEWEIHUODEPIZHUN。

[a]XIRUXINGTANGPIZHIJISU

[b]ZHANGXIAOB-2SHOUTIJIDONGJI

[c]MEITIANYIBAOYANDEXIYANSHIDADAO10NIAN

关于噻托溴铵

不用本金就能赚钱的方法SAITUOXIUANSHIYIZHONGZHANGXIAOXIRUXINGKANGDANJIANNENGZHIQIGUANKUOZHANGJI,YESHISHOUGEMEIRIYICIJIYAOJIUNENGXIANZHUCHIJIUGAISHANCOPDHUANZHEFEIGONGNENGDEXIRUWEICHIZHILIAOYAOWU。SAITUOXIUANJUYOUSHUZHANGXIAZHAIQIDAODEZUOYONG,BINGSHIQIDAOBAOCHIKAIFANGZHUANGTAIZHANGDA24XIAOSHI。

不用本金就能赚钱的方法SAITUOXIUANYINGYONGYUXIAOCHUANZHILIAODELINCHUANGKAIFAJIHUAZHENGYOUBOLINGEYINGEHANGONGSIHEHUIRUIGONGSILIANHEKAIZHANZHONG,BINGYOUBOLINGEYINGEHANGONGSIFUZEGUANLISUOYOULINCHUANGYANFAHUODONGDESHISHI。BOLINGEYINGEHANGONGSIYUHUIRUIGONGSIMUQIANSUODIJIEDELIANMENGHEYUEYUNXULIANGJIAGONGSIGONGTONGCANYUCHANPINDESHANGYEHUA。

关于能倍乐(Respimat)® 不用本金就能赚钱的方法Soft Mist™吸入器

由勃林格殷格翰公司研发的能倍乐(Respimat)® 不用本金就能赚钱的方法Soft Mist™ 吸入器(SMI)是新一代吸入装置,这种吸入器可产生独特的轻雾Soft Mist™[11,12],后者更容易被患者吸入[13],因此,与其他现有吸入装置相比, 也更受患者青睐[14-15]。

BOLINGEYINGEHANGONGSI:YINLINGHUXIJIBINGLINGYUZHILIAOJINBU

ZAIGUOQUDEJIUSHIDUONIANJIAN,HUXIXITONGJIBINGSHIZHONGSHIBOLINGEYINGEHANGONGSIQUANLIYIFUDEZHUYAOZHILIAOLINGYU,GONGSIYIJINGZAICILINGYUTOURULEDALIANGZIYUAN。

勃林格殷格翰公司拥有在呼吸疾病领域的悠久的开拓历史,并开发了迄今为止获得最多研究和最高处方量的、作为每日一次维持治疗的COPD处方药物思力华®。公司也已向其他气道疾病领域进行了拓展,以开发相关的治疗选择,这些领域包括哮喘、肺癌和特发性肺纤维化。

WOMENZAIHUXIJIBINGZHILIAOLINGYUPENGBOFAZHANDETUIDONGLILAIZIZAIJIEJUEFUZADEKEXUENANTIFANGMIANDELINGDAOLIHEREQING,ZHEIXIEKEXUENANTISHEJIHUANZHEMUQIANLIHUANHEJIANGLAIHUIMIANLINDEFEIBUJIBING。

勃林格殷格翰公司

BOLINGEYINGEHANGONGSISHIQUANQIUPAIMINGQIAN20WEIDEZHIYAOGONGSIZHIYI。ZONGBUWEIYUDEGUOYINGEHAN,YONGYOU140JIAZIGONGSIHECHAOGUO46,000MINGYUANGONG。ZICONG1885NIANCHENGLIYILAI,ZHEIJIAJIAZUQIYEYIZHIZHILIYUYANFA、ZHIZAOJITUIGUANGGEZHONGDUIRENLEIHEDONGWUJUYOUJIGAOZHILIAOJIAZHIDECHUANGXINYAOPIN。

ZUOWEIGONGSIWENHUADEHEXINCHENGFEN,BOLINGEYINGEHANSHIZHONGCHENGNUODANFUSHEHUIZEREN,CONGCANYUSHEHUIGONGYIXIANGMU,DAOGUANAIYUANGONGJIQIJIASHUHEZAIQUANQIUXINGYINGYUNJICHUSHANGWEISUOYOUYUANGONGTIGONGJUNDENGDEJIHUI。HUXIANGHEZUOHEZUNZHONG、BAOHUHUANJINGHEKECHIXUXINGFAZHANGOUCHENGLEBOLINGEYINGEHANGONGSISUOYOUNULIDEHEXINYINSU。

ZAI2012NIAN,BOLINGEYINGEHANGONGSIJINGXIAOSHOUEDA147YIOUYUAN,GONGSIJIANGQICHUFANGYAOYEWUXIAOSHOUEDE22.5%TOURUYUYANFAGONGZUO。

GENGDUOXINXI,QINGDENGLU

不用本金就能赚钱的方法BOLINGEYINGEHANBUYONGBENJINJIUNENGZHUANQIANDEFANGFAFABUZHUYE:WEIJIZHETIGONGDECHUANGXINXINGXINXILAIYUAN

不用本金就能赚钱的方法BOLINGEYINGEHANGONGSIHUXILINGYUXINWENYIJINGFABUZAISHANG,GAIWANGZHANSHIYIZHANSHIDEXINXIHUODETUJING,TIGONGLEQINGXI、JIANMING、YIDONGDEYOUGUANXIAOCHUANHEQITAHUXIXITONGJIBINGDEMEITICANKAOXINXI。

HUIRUIGONGSI:XIESHOUCHUANGZAOYIGEGENGJIAJIANKANGDESHIJIE™

ZAIHUIRUI,WOMENLIYONGKEXUEJISHUHEQUANQIUZIYUANZHILIYUGAISHANGEGENIANLINGDUANRENQUNDEJIANKANGSHUIPING。WOMENJIEJINQUANLIZAIFAMING、KAIFAHEZHIZAORENYONGYAOPINHEDONGWUBAOJIANCHANPINDEGUOCHENGZHONGCHUANGLILEZHILIANG、ANQUANXINGHEJIAZHIGUANBIAOZHUN。

WOMENJUYOUDUOYUANHUADEQUANQIUYILIAOCHANPINKU,BAOKUORENYONGHEDONGWUYONGDESHENGWUYAOPINHEXIAOFENZIYAOPINJIYIMIAO,CIWAIHAIYONGYOUYINGYANGCHANPINHEZHUDUOZAIQUANQIUXIANGYOUSHENGYUDEFEICHUFANGYAOWU。

不用本金就能赚钱的方法MEIYITIAN,CONGCHENGSHUSHICHANGDAOXINXINGSHICHANG,HUIRUIYUANGONGDOUTONGGUOXINQINGONGZUOBUDUANTISHENGBAOJIAN、YUFANG、ZHILIAOHEZHIYUSHUIPING,JINERWEINEIXIEDANGQIANZUIWEIJISHOUDEJIBINGTIGONGJIEJUEFANGAN。YUWOMENZUOWEIQUANQIULINGXIANDESHENGWUZHIYAOGONGSIDEZERENXIANGYIZHIDESHI,WOMENHAIYUYILIAOFUWUTIGONGFANG、ZHENGFUHESHEQUJINMIHEZUO,CONGERZAIQUANQIUFANWEINEIZHICHIBINGKUODANEIXIEKEKAODE、KECHENGSHOUDEYILIAOFUWUDEKEHUODEXING。ZAIGUOQU150DUONIANYILAI,HUIRUIGONGSIZHILIYUWEINEIXIEFUYUWOMENZHONGTUODERENMENCHUANGZAOBUYIYANGDESHENGHUO。

不用本金就能赚钱的方法RUGUOYAOLEJIEGENGDUOYOUGUANWOMENDESHIMINGDEXINXI,QINGDENGLUYIXIAWANGZHAN:

References

  1. Kerstjens HAM, Tashkin DP, Engel M et al. Tiotropium decreases the risk of exacerbations in patients with symptomatic asthma regardless of baseline characteristics. Am J Respir Crit Care Med 2013; 187: A4217
  2. Halpin DM, Bateman ED, Moroni-Zentgraf P, et al. Tiotropium is effective in patients with severe asthma without evidence of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187: A2731
  3. , , , et al; . Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study.   2004;170 (8): 836-44
  4. Kerstjens HAM, Dahl R, Beck E, et al. Tiotropium reduces asthma exacerbations in asthmatic patients with persistent airflow obstruction uncontrolled despite treatment in accordance with guidelines. Eur Respir J 2012; 40: Suppl. 56, 313S abstract P1796
  5. Kerstjens HAM, Paggiaro PL, Vandewalker et al. Tiotropium provides sustained bronchodilation in asthmatics with persistent airflow obstruction uncontrolled despite treatment in accordance with guidelines. Eur Respir J 2012; 40: Suppl. 56, 391S abstract P2187
  6. Global Initiative for Asthma. Pocket guide for asthma management and prevention. Available at:  [Last Accessed 11/04/13]
  7. World Health Organization. WHO factsheet 307: bronchial asthma. Available at: [Last Accessed 11/04/13]
  8. . The global burden of asthma.  2006 Jul;130(1 Suppl):4S-12S
  9. Global Initiative for Asthma.  published in 2003 [Last Accessed 11/04/13]
  1. World Health Organization. WHO factsheet 206: bronchial asthma. Available at: [Last Accessed 11/04/13]
  2. Dhand R. Aerosol Plumes: Slow and steady wins the race. J Aerosol Med 2005; 18(3): 261-63
  3. Hochrainer D, Holz H. Comparison of aerosol velocity and spray duration of Respimat® Soft MistTM Inhaler and pressurized Metered Dose Inhalers. J Aerosol Med 2005; 18(3): 273-282
  4. Kardos P, Golisch W, Wolf K. New SoftMistTM Inhaler is effective and easy to use in patients with asthma and COPD. Eur Respir J 2005; 26 (Suppl 49): 338s
  5. Hodder R, Reese PR, Slaton T. Asthma patients prefer Respimat® Soft MistTM Inhaler to Turbohaler. Int J Chronic Obstruct Pulm Dis 2009; 4: 225-232
消息来源: 勃林格殷格翰
(来源: 美通社


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